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Journal Article

Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis

MPS-Authors

Herr,  Alexander
Max Planck Society;

Meunier,  Dominique
Max Planck Society;

Muller,  Ines
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50161

Fundele,  Reinald
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50501

Ropers,  Hans-Hilger
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50450

Nuber,  Ulrike A.
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Herr, A., Meunier, D., Muller, I., Rump, A., Fundele, R., Ropers, H.-H., et al. (2003). Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis. Developmental Dynamics, 226(4), 579-586. doi:10.1002/dvdy.10260.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8A75-8
Abstract
TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region. Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse Tbx22 and analyzed its expression during embryogenesis by reverse transcriptase-polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in the tongue frenulum perfectly correlates with the ankyloglossia phenotype in CPX. Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2).