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Error models for microarray intensities

MPS-Authors

von Heydebreck,  Anja
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50613

Vingron,  Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Huber, W., von Heydebreck, A., & Vingron, M. (2004). Error models for microarray intensities. Berkeley, CA: Berkeley Electronic Press.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-88AD-B
Abstract
We derive the additive-multiplicative error model for microarray intensities, and describe two applications. For the detection of differentially expressed genes, we obtain a statistic whose variance is approximately independent of the mean intensity. For the post hoc calibration (normalization) of data with respect to experimental factors, we describe a method for parameter estimation.