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Tipping the balance toward longevity

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50070

Antebi,  Adam
Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Antebi, A. (2004). Tipping the balance toward longevity. Developmental Cell, 6(3), 315-316. doi:10.1016/S1534-5807(04)00068-1.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8899-8
Abstract
Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.