Whole-genome approaches for large-scale gene identification and expression 
analysis in mammalian preimplantation embryos

Adjaye, James

doi:10.1071/RD04075

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos

MPS-Authors

/persons/resource/persons50054

Adjaye, James
Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

Adjaye - Reprod Fertil Dev..pdf
(Any fulltext), 601KB

Supplementary Material (public)

There is no public supplementary material available

Citation

Adjaye, J. (2005). Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos. Reproduction, Fertility and Development, 17(2), 37-45. doi:10.1071/RD04075.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-872F-2

Abstract

The elucidation, unravelling and understanding of the molecular basis of transcriptional control during preimplantion development is of utmost importance if we are to intervene and eliminate or reduce abnormalities associated with growth, disease and infertility by applying assisted reproduction. Importantly, these studies should enhance our knowledge of basic reproductive biology and its application to regenerative medicine and livestock production. A major obstacle impeding progress in these areas is the ability to successfully generate molecular portraits of preimplantation embryos from their minute amounts of RNA. The present review describes the various approaches whereby classical embryology fuses with molecular biology, high-throughput genomics and systems biology to address and solve questions related to early development in mammals.