twilight; a Bioconductor package for estimating the local false discovery rate

Scheid, Stefanie; Spang, Rainer

doi:10.1093/bioinformatics/bti436

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twilight; a Bioconductor package for estimating the local false discovery rate

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Scheid, Stefanie
Max Planck Society;

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Spang, Rainer
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Scheid, S., & Spang, R. (2005). twilight; a Bioconductor package for estimating the local false discovery rate. Bioinformatics, 21(12), 2921-2922. doi:10.1093/bioinformatics/bti436.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-868C-7

Abstract

Summary: twilight is a Bioconductor compatible package for analysing the statistical significance of differentially expressed genes. It is based on the concept of the local false discovery rate (FDR), a generalization of the frequently used global FDR. twilight implements the heuristic search algorithm for estimating the local FDR introduced in our earlier work. In addition to the raw significance measures, it produces diagnostic plots, which provide insight into the extent of differential expression across genes.