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Journal Article

SVC: structured visualization of evolutionary sequence conservation

MPS-Authors

Roepcke,  Stefen
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50613

Vingron,  Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Fulltext (public)

W271.pdf
(Any fulltext), 88KB

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Citation

Roepcke, S., Fiziev, P., Seeburg, P. H., & Vingron, M. (2005). SVC: structured visualization of evolutionary sequence conservation. Web Server Issue, W271-W273. Retrieved from 10.1093/nar/gki589.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-866D-D
Abstract
We have developed a web application for the detailed analysis and visualization of evolutionary sequence conservation in complex vertebrate genes. Given a pair of orthologous genes, the protein-coding sequences are aligned. When these sequences are mapped back onto their encoding exons in the genomes, a scaffold of the conserved gene structure naturally emerges. Sequence similarity between exons and introns is analysed and embedded into the gene structure scaffold. The visualization on the SVC server provides detailed information about evolutionarily conserved features of these genes. It further allows concise