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Journal Article

Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality

MPS-Authors

Ruiz,  Patricia
Max Planck Society;

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Hitz et al. - genesis.pdf
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Citation

Hitz, C., Vogt-Weisenhorn, D., Ruiz, P., Wurst, W., & Floss, T. (2005). Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality. Genesis, 42(2), 91-103. doi:10.1002/gene.20128.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-864A-C
Abstract
We have generated a mouse line with a mutant allele of the mouse Bruce/Birc6 gene induced by gene trap mutagenesis. Based on its structural features, Bruce is a member of the family of apoptosis inhibitor proteins (IAPs). This mutation leads to a truncated transcript and protein and results in a complete loss of the wildtype Bruce protein. Bruce mutant mice die from a progressive loss of their placental spongiotrophoblast layer between day 11.5 and 14.5 of embryonic development. The cause of the Bruce homozygous mutant phenotype is a lack of proliferation of spongiotrophoblast cells in the developing placenta. In contrast to in vitro data, which indicate a function for Bruce in apoptosis inhibition, the in vivo results presented here suggest instead a role for Bruce in cell division.