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Book Chapter

Modelling of signal transduction in yeast – sensitivity and model analysis

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Klipp,  Edda
Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

Schaber,  Jörg
Max Planck Society;

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KlippSysBiol.pdf
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Citation

Klipp, E., & Schaber, J. (2006). Modelling of signal transduction in yeast – sensitivity and model analysis. In M. Cánovas, J. L. Iborra, & A. Manjón (Eds.), Understanding and exploiting systemy biology in bioprocesses and biomedicine (pp. 15-30). Murcia: Fundación Cajamurcia.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8509-4
Abstract
Experimental research has revealed components and mechanisms of cellular stress sensing and adaptation. In addition, mathematical modelling has proven to foster the understanding of some basic principles of signal transduction and signal processing as well as of sensitivity and robustness of information perception and cellular response. Here we review some modelling principles, results and open questions exemplified for a model organism, the yeast Saccharomyces cerevisiae.