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About the interrelation of evolutionary rate and protein age

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50417

Luz,  Hannes
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

Staub,  Eike
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50613

Vingron,  Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zitation

Luz, H., Staub, E., & Vingron, M. (2006). About the interrelation of evolutionary rate and protein age. Genome Informatics: Japanese Society for Bioinformatics, 17(1), 240-250.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-84EE-C
Zusammenfassung
Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic distribution in the gene family. This is because homology detection by sequence comparison is depending on sequence similarity. We estimate family specific rates of protein evolution for orthologous families with representatives from man, fugu, fly, and worm. In fact, we observe that younger proteins tend to evolve faster than older ones. We estimate time points of duplication events that gave rise to novel protein functions and show that younger proteins were duplicated more recently than older ones.