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Family specific rates of protein evolution

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50417

Luz,  Hannes
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50613

Vingron,  Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zitation

Luz, H., & Vingron, M. (2006). Family specific rates of protein evolution. Bioinformatics, 10, 1166-1171. doi:10.1093/bioinformatics/btl073.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-847B-C
Zusammenfassung
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.