Family specific rates of protein evolution

Luz, Hannes; Vingron, Martin

doi:10.1093/bioinformatics/btl073

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Family specific rates of protein evolution

MPS-Authors

/persons/resource/persons50417

Luz, Hannes
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

/persons/resource/persons50613

Vingron, Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Luz, H., & Vingron, M. (2006). Family specific rates of protein evolution. Bioinformatics, 10, 1166-1171. doi:10.1093/bioinformatics/btl073.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-847B-C

Abstract

Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.