Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental 
Patterning and Morphogenesis in Vertebrate Somitogenesis

Dale, Jacqueline Kim; Malapert, Pascale; Chal, Jérome; Vilhais-Neto, Gonçalo; Herrmann, Bernhard; Maroto, Miguel; Johnson, Teri; Jayasinghe, Sachintha; Pourquié, Olivier

doi:10.1016/j.devcel.2006.02.011

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis

MPS-Authors

Herrmann, Bernhard
Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Dale, J. K., Malapert, P., Chal, J., Vilhais-Neto, G., Herrmann, B., Maroto, M., et al. (2006). Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis. Developmental Cell, 10(3), 355-366. doi:10.1016/j.devcel.2006.02.011.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8476-5

Abstract

The segmented body plan of vertebrate embryos arises through segmentation of the paraxial mesoderm to form somites. The tight temporal and spatial control underlying this process of somitogenesis is regulated by the segmentation clock and the FGF signaling wavefront. Here, we report the cyclic mRNA expression of Snail1 and Snail2 in the mouse and chick presomitic mesoderm (PSM), respectively. Whereas Snail genes' oscillations are independent of NOTCH signaling, we show that they require WNT and FGF signaling. Overexpressing Snail2 in the chick embryo prevents cyclic Lfng and Meso1 expression in the PSM and disrupts somite formation. Moreover, cells misexpressing Snail2 fail to express Paraxis, remain mesenchymal, and are thereby inhibited from undergoing the epithelialization event that culminates in the formation of the epithelial somite. Thus, Snail genes define a class of cyclic genes that coordinate segmentation and PSM morphogenesis.