de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer

MPS-Authors

Staub,  Eike
Max Planck Society;

Röpcke,  Stefan
Max Planck Society;

Locator
There are no locators available
Fulltext (public)

1476-4598-5-37.pdf
(Any fulltext), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Staub, E., Gröne, J., Mennerich, D., Röpcke, S., Klamann, I., Hinzmann, B., et al. (2006). A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer. Molecular Cancer, 5, 37-37. doi:10.1186/1476-4598-5-37.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-83A9-A
Abstract
Background: Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression. Results: We investigated genome-wide gene expression in colorectal carcinoma (CRC) and normal epithelial tissues from 25 patients using oligonucleotide arrays. This allowed us to identify 81 distinct chromosomal islands with aberrant gene expression. Of these, 38 islands show a gain in expression and 43 a loss of expression. In total, 7.892 genes (25.3% of all human genes) are located in aberrantly expressed islands. Many chromosomal regions that are linked to hereditary colorectal cancer show deregulated expression. Also, many known tumor genes localize to chromosomal islands of misregulated expression in CRC. Conclusion: An extensive comparison with published CGH data suggests that chromosomal regions known for frequent deletions in colon cancer tend to show reduced expression. In contrast, regions that are often amplified in colorectal tumors exhibit heterogeneous expression patterns: even show a decrease of mRNA expression. Because for several islands of deregulated expression chromosomal aberrations have never been observed, we speculate that additional mechanisms (like abnormal states of regional chromatin) also have a substantial impact on the formation of co-expression islands in colorectal carcinoma.