de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

A centrosome-independent role for {gamma}-TuRC proteins in the spindle assembly checkpoint

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50436

Müller,  Hannah
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50156

Fogeron,  Marie-Laure
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Lehmann,  Verena
Max Planck Society;

Lehrach,  Hnas
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50403

Lange,  Bodo M. H.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

LangeB.pdf
(Any fulltext), 272KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Müller, H., Fogeron, M.-L., Lehmann, V., Lehrach, H., & Lange, B. M. H. (2006). A centrosome-independent role for {gamma}-TuRC proteins in the spindle assembly checkpoint. Science, 314(5799), 654-657. doi:10.1126/science.1132834.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8367-B
Abstract
The spindle assembly checkpoint guards the fidelity of chromosome segregation. It requires the close cooperation of cell cycle regulatory proteins and cytoskeletal elements to sense spindle integrity. The role of the centrosome, the organizing center of the microtubule cytoskeleton, in the spindle checkpoint is unclear. We found that the molecular requirements for a functional spindle checkpoint included components of the large {gamma}-tubulin ring complex ({gamma}-TuRC). However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation.