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Journal Article

The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome

MPS-Authors
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Qin,  Yan
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

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Vesper,  Oliver
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

Staub,  Eike
Max Planck Society;

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Einfeldt,  Edda
Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Wilson,  Daniel N.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Nierhaus,  Knud
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Qin, Y., Polacek, N., Vesper, O., Staub, E., Einfeldt, E., Wilson, D. N., et al. (2006). The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome. Cell, 127(4), 721-733. doi:10.1016/j.cell.2006.09.037.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8336-A
Abstract
The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes, and the results suggest that it recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly. We suggest renaming LepA as elongation factor 4 (EF4).