de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Buchkapitel

Analysis of fused in-situ hybridization and gene expression data.

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50523

Schliep,  Alexander
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Opitz, L., Schliep, A., & Posch, A. (2007). Analysis of fused in-situ hybridization and gene expression data. In Advances in Data Analysis (pp. 577-584). Berlin/Heidelberg: Springer.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-82DE-B
Zusammenfassung
To understand transcriptional regulation during development a detailed analysis of gene expression is needed. In-situ hybridization experiments measure the spatial distribution of mRNA-molecules and thus complement DNA-microarray experiments. This is of very high biological relevance, as co-location is a necessary condition for possible molecular interactions. We use publicly available in-situ data from embryonal development of Drosophila and derive a co-location index for pairs of genes. Our image processing pipeline for in-situ images provides a simpler alternative for the image processing part at comparable performance compared to published prior work. We formulate a mixture model which can use the pair-wise co-location indices as constraints in a mixture estimation on gene expression time-courses.