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Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.

MPS-Authors

Gurok,  Ulf
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50450

Nuber,  Ulrike
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50566

Spörle,  Ralf
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Gurok, U., Bork, K., Nuber, U., Spörle, R., Nöhring, S., & Horstkorte, R. (2007). Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development. Mechanisms of Development: Gene Expression Patterns: Gep; A Section of Mechanisms of Development, 7(3), 370-374. doi:10.1016/j.modgep.2006.07.004.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8276-2
Abstract
Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3–Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.