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Journal Article

Telomere attachment and clustering during meiosis.

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50515

Scherthan,  Harry
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Scherthan, H. (2007). Telomere attachment and clustering during meiosis. Cellular and Molecular Life Sciences: CMLS, 64(2), 117-124. doi:10.1007/s00018-006-6463-2.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8270-E
Abstract
Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.