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The oxazolidinone class of drugs find their orientation on the ribosome

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Wilson,  Daniel N.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Nierhaus,  Knud H.
Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Wilson, D. N., & Nierhaus, K. H. (2007). The oxazolidinone class of drugs find their orientation on the ribosome. Molecular Cell, 26(4), 460-462. doi:10.1016/j.molcel.2007.05.008.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-81C6-5
Abstract
Recent studies by Leach et al. (2007) in Molecular Cell identify the orientation of the oxazolidinone antibiotic linezolid at the peptidyltransferase center of bacterial and mitochondrial ribosomes, providing a structural basis for the mechanism of drug action and observed side effects.