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Journal Article

Transcriptional regulation at a glance

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50492

Sperling,  Silke
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Sperling, S. (2007). Transcriptional regulation at a glance. BMC Bioinformatics, 8(Suppl. 6), S2-S2. doi:10.1186/1471-2105-8-S6-S2.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8177-8
Abstract
Considering that 80 genomes have been sequenced, providing us with the static information of the genome, it is still a long way to reveal the relationship between complex genotypes and phenotypes. The transcriptional regulation process is one of the obstacles that need to be understood to bridge our current information gap. It describes the first step from the genomic sequence information to RNA templates used for protein production or as direct functional units, like non-coding RNAs (e.g. micro RNAs). This introduction aims to highlight the key aspects of the transcriptional process from our current understanding.