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Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50646

Witte,  Florian
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

Dokas,  Janine
Max Planck Society;

Neuendorf,  Franziska
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50437

Mundlos,  Stefan
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50578

Stricker,  Sigmar
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Witte, F., Dokas, J., Neuendorf, F., Mundlos, S., & Stricker, S. (2009). Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expression Patterns, 9(4), 215-223. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W8W-4VC7DXP-1-1F&_cdi=6665&_user=127795&_pii=S1567133X08001439&_orig=browse&_coverDate=04%2F30%2F2009&_sk=999909995&view=c&wchp=dGLbVlW-zSkzS&md5=ee8d4fcc41398313229ff0817c26e751&ie=/sdarticle.pdf.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7DC4-0
Abstract
Wnt signalling plays important roles in patterning and outgrowth of the vertebrate limb. Different mutations in Wnt genes, their antagonists or (co-)receptors result in patterning and outgrowth defects as well as chondrocyte and bone phenotypes in mouse and human. Understanding Wnt activity during mouse limb development and chondrogenesis requires a temporal and spatial overview of Wnt signalling key factor expression. Here we present a comparative expression analysis of all 19 Wnt genes and their major secreted antagonists of the Dickkopf (Dkk), Wisp and the secreted frizzled related protein (Sfrp) families during mouse limb development. Our study reveals new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. We also identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5, Wisp1 as well as Dkk2 and Dkk3. We provide a full expression pattern for Wif1 in limb development, for which no limb expression had been documented so far.