de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

DNA Damage by Low-Energy Electron Impact: Dependence on Guanine Content.

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50550

Seitz,  Harald
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Solomun, T., Seitz, H., & Sturm, H. (2009). DNA Damage by Low-Energy Electron Impact: Dependence on Guanine Content. Journal of Physical Chemistry B, 113(34), 11557-11559. doi:10.1021/jp905263x.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7D42-1
Abstract
Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n = 1−4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.