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Automation in the high-throughput selection of random combinatorial libraries-different approaches for select applications

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50167

Glökler,  J.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50536

Schütze,  T.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50390

Konthur,  Z.
In vitro Ligand Screening (Zoltán Konthur), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Glökler.pdf
(Any fulltext), 268KB

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Citation

Glökler, J., Schütze, T., & Konthur, Z. (2010). Automation in the high-throughput selection of random combinatorial libraries-different approaches for select applications. Molecules, 15(4), 2478-2490. doi:10.3390/molecules15042478.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7B7D-F
Abstract
Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.