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Journal Article

Obesity and the brain: a possible genetic link

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50098

Bertram,  Lars
Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Bertram.pdf
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Citation

Bertram, L., & Heekeren, H. (2010). Obesity and the brain: a possible genetic link. Alzheimer's Research & Therapy, 2(5), 2:27-2:27. doi:10.1186/alzrt51.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7A3F-5
Abstract
Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined.