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Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50098

Bertram,  L.
Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zitation

Bertram, L. (2011). Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'. Current Neurology and Neuroscience Reports, 11(3), 246-53. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21487954 http://www.springerlink.com/content/f875645430247116/fulltext.pdf.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-7875-A
Zusammenfassung
After a decade of intensive investigation but only few replicable results, Alzheimer's disease (AD) genetics research is slowly picking up pace. This is mostly owing to the completion of several genome-wide association studies (GWAS), which have suggested the existence of over three dozen potential new AD susceptibility genes. Although only a handful of these could be confirmed in subsequent independent replication efforts to date, this success rate is still much higher than in the pre-GWAS era. This review provides a brief summary of the principal methodologic advances in genetics research of the past decade, followed by a description of the most compelling findings that these advances have unearthed in AD. The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research.