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Preliminary X-ray crystallographic study of the proteasome from Thermoplasma acidophilum

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Zitation

Jap, B., Pühler, G., Lücke, H., Typke, D., Löwe, J., Stock, D., et al. (1993). Preliminary X-ray crystallographic study of the proteasome from Thermoplasma acidophilum. Journal of Molecular Biology., 234(3), 881-884.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-73C5-7
Zusammenfassung
Single cystals of proteasomes from the archaebacterium Thermoplasma acidophilum were obtained using the hanging-drop vapor diffusion method. The crystals diffract to better than 3.0 A and belong to the orthorhombic space group P2(1)2(1)2(1) with unit cell dimensions a = 308.9 A, b = 208.8 A and c = 116.9 A. There is one molecular complex in the asymmetric unit. Two potentially useful heavy-atom derivatives have been obtained. The self-rotation function of the native Patterson map shows local sevenfold symmetry, consistent with the low-resolution structure obtained by electron microscopic techniques. The unit cell dimensions and crystal symmetry together with the shape and size of the proteasome suggest a packing arrangement of proteasome molecules in the unit cell, with their cylinder axis nearly parallel to the crystallographic a-axis.