Existence of a molecular ruler in proteasomes suggested by analysis of 
degradation products

Wenzel, T.; Eckerskorn, C.; Lottspeich, F.; Baumeister, W.

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Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

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Wenzel, T., Eckerskorn, C., Lottspeich, F., & Baumeister, W. (1994). Existence of a molecular ruler in proteasomes suggested by analysis of degradation products. FEBS Letters., 349(2), 205-209.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-738F-3

Abstract

Analysis of the degradation products from two proteins, the insulin B-chain and human hemoglobin, generated by archaebacterial Thermoplasma acidophilum 20 S proteasomes, revealed an unexpectedly broad specificity. In spite of the vast number of different peptides found, they fell into a rather narrow size range. This suggests that a molecular ruler exists which determines the length of the cleavage products.