Proteasome: from structure to function

Stock, D.; Nederlof, P. M.; Seemüller, E.; Baumeister, W.; Huber, R.; Löwe, J.

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Proteasome: from structure to function

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Stock, D., Nederlof, P. M., Seemüller, E., Baumeister, W., Huber, R., & Löwe, J. (1996). Proteasome: from structure to function. Current Opinion in Biotechnology., 7(4), 376-385.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-7315-6

Abstract

During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily. [References: 75]