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Tricorn protease - the core of a modular proteolytic system

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Citation

Tamura, T., Tamura, N., Cejka, Z., Hegerl, R., Lottspeich, F., & Baumeister, W. (1996). Tricorn protease - the core of a modular proteolytic system. Science, 274(5291), 1385-1389.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-72CE-E
Abstract
Large macromolecular assemblies have evolved as a means of compartmentalizing reactions in organisms lacking membrane-bounded compartments. A tricorn-shaped protease was isolated from the archaeon Thermoplasma and was shown to form a multisubunit proteolytic complex. The 120-kilodalton monomer assembled to form a hexameric toroid that could assemble further into a capsid structure. Tricorn protease appeared to act as the core of a proteolytic system; when it interacted with several smaller proteins, it displayed multicatalytic activities. [References: 31]