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Journal Article

Predicting Coiled-coil Regions in Proteins

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Citation

Lupas, A. (1997). Predicting Coiled-coil Regions in Proteins. Curr. Opin. Struct. Biol., 7(3), 388-393.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-72B4-6
Abstract
The past several years have seen significant advances in our ability to recognize coiled coils from protein sequences and model their structures. New methods include a detection program based on pairwise residue correlations, a program that distinguishes two-stranded from three-stranded coiled coils and a routine for modeling the coordinates of the core residues in coiled coils. Several widely noted predictions, among them those for heterotrimeric G proteins and for cartilage oligomeric matrix protein, have been confirmed by crystal structures, and several new predictions have been made, including a model for the still hypothetical right-handed coiled coil.