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The thermosome - alternating alpha and beta-subunits within the chaperonin of the archaeon thermoplasma acidophilum

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Zitation

Nitsch, M., Klumpp, M., Lupas, A., & Baumeister, W. (1997). The thermosome - alternating alpha and beta-subunits within the chaperonin of the archaeon thermoplasma acidophilum. Journal of Molecular Biology, 267(1), 142-149.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-729C-D
Zusammenfassung
The thermosome of the archaeon Thermoplasma acidophilum is composed of two subunits, alpha and beta, which are arranged in two stacked, eight-membered rings. Electron cryo-microscopy in conjunction with image analysis revealed a 4-fold symmetry in the heterooligomeric alpha + beta thermosome isolated from Thermoplasma, but not in the homooligomeric alpha-only thermosome expressed in Escherichia coli. This indicates that alpha and P-subunits alternate within the rings of the Thermoplasma thermosome rather than forming two different homooligomeric rings. In addition, a small subpopulation of 9-fold symmetric complexes was found among the recombinant alpha-only thermosomes, and a central mass most likely representing bound substrate molecules was observed in about half of the native and recombinant thermosome particles. (C) 1997 Academic Press Limited. [References: 36]