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Structural research on surface layers: A focus on stability, surface layer homology domains, and surface layer cell wall interactions

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Zitation

Engelhardt, H., & Peters, J. (1998). Structural research on surface layers: A focus on stability, surface layer homology domains, and surface layer cell wall interactions. Journal of Structural Biology, 124(2-3), 276-302.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-725E-C
Zusammenfassung
Surface layers (S-layers) from Bacteria and Archaea are built from protein molecules arrayed in a two-dimensional lattice, forming the outermost cell wall layer in many prokaryotes. In almost half a century of S-layer research a wealth of structural, biochemical, and genetic data have accumulated, but it has not been possible to correlate sequence data with the tertiary structure of S-layer proteins to date. In this paper, some highlights of structural aspects of archaeal and bacterial S-layers that allow us to draw some conclusions on molecular properties are reviewed. We focus on the structural requirements for the extraordinary stability of many S-layer proteins, the structural and functional aspects of the S-layer homology domain found in S-layers, extracellular enzymes and related functional proteins, and outer membrane proteins, and the molecular interactions of S-layer proteins with other cell wall components. Finally, the perspectives and requirements for structural research on S-layers, which indicate that the investigation of isolated protein domains will be a prerequisite for solving S-layer structures at atomic resolution, are discussed. (C) 1998 Academic Press. [References: 181]