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The thermosome - archetype of group ii chaperonins

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Klumpp, M., & Baumeister, W. (1998). The thermosome - archetype of group ii chaperonins. FEBS Letters, 430(1-2 Special Issue SI), 73-77.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-7205-1
Abstract
The thermosome, the chaperonin of the archaea, and its homologue from the cytosol of eukaryotes, known as TRiC or CCT, form a distinct subfamily of the chaperonins that does not depend on a co-chaperonin for protein folding activity. Recent structural data obtained by cryo- electron microscopy and X-ray crystallography provide the first insights into a novel mechanism remarkably different from that of the bacterial GroEL-GroES system. (C) 1998 Federation of European Biochemical Societies. [References: 49]