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Nonlinear and asymmetric open channel characteristics of an ion-selective porin in planar membranes

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Zitation

Mathes, A., & Engelhardt, H. (1998). Nonlinear and asymmetric open channel characteristics of an ion-selective porin in planar membranes. Biophysical Journal, 75(3), 1255-1262.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-71F9-3
Zusammenfassung
The open channel characteristics of the bacterial porin Omp32 from Comamonas acidovorans were investigated by means of conductance measurements in planar lipid bilayers of the Montal-Mueller type. Particularly at low salt conditions (less than or equal to 30 mM KCI) Omp32 exhibited some unusual asymmetric and nonlinear functional properties. Current-voltage relationship measurements showed that conductance depends on the orientation of porin molecules and is a nonlinear function of the applied membrane potential. Conductance also depends on the salt concentration in a manner not common to porins and the salt concentration modulates the nonlinearity of conductance-voltage relationships. Omp32 is strongly anion-selective. The nonlinear and asymmetric conductance of the open channel is a new observation in porins. [References: 44]