Proteasomes and other self-compartmentalizing proteases in prokaryotes

De Mot, R.; Nagy, I.; Walz, J.; Baumeister, W.

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Proteasomes and other self-compartmentalizing proteases in prokaryotes

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De Mot, R., Nagy, I., Walz, J., & Baumeister, W. (1999). Proteasomes and other self-compartmentalizing proteases in prokaryotes. Trends in Microbiology., 7(2), 88-92.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-71D1-C

Abstract

The proteasome represents the major non-lysosomal proteolytic system in eukaryotes. It confines proteolytic activity to an inner compartment that is accessible to unfolded proteins only. The strategy of controlling intracellular breakdown of proteins by self-compartmentalization is also used by different types of prokaryotic energy-dependent proteases. Genomic sequencing data reveal that various combinations of these energy-dependent proteases occur in prokaryotic cells from different lineages. [References: 33]