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Macromolecular electron microscopy in the era of structural genomics

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Baumeister, W., & Steven, A. C. (2000). Macromolecular electron microscopy in the era of structural genomics. Trends in Biochemical Sciences, 25(12), 624-631.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-7189-1
Abstract
Macromolecular machines carry out many cellular functions. Cryo-electron microscopy (cryo-EM) is emerging as a powerful method for studying the structure, assembly and dynamics of such macromolecules, and their interactions with substrates. With resolutions still improving, 'single-particle' analyses are already depicting secondary structure. Moreover, cryo-EM can be combined in several ways with X-ray diffraction to enhance the resolution of cryo-EM and the applicability of crystallography. Electron tomography holds promise for visualizing machines at work inside cells. [References: 62]