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Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons77804

Braun,  A.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons77685

Aszodi,  A.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons77945

Fässler,  R.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons77800

Brandau,  O.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Braun, A., Aszodi, A., Hellebrand, H., Berna, A., Fässler, R., & Brandau, O. (2002). Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis. Gene, 283(1-2), 219-225.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-6FE4-8
Zusammenfassung
Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFNI), profilin-II (PEN2) with two splice variants and the recently identified profilin-III (PFN3). Here we describe the genomic organization of the genes encoding human and mouse profilin-Ill, Both are single exon genes and lie in close vicinity to the renal sodium-phosphate transport gene 2 (SLC34A1, NPT2) which is highly expressed in kidney. Northern hybridization to rat tissues has previously demonstrated expression of an approximately 4.5 kb long profilin-III mRNA transcript in kidney and a mRNA transcript of approximately 1 kb in length in testis. Here we show that mouse profilin-III expression is restricted to testis and that the 4.2 kb profilin-III mRNA in kidney is the result of a slc34a1 transcript which includes the antisense profilin-III open reading frame in its 3'-untranslated region. Finally, we demonstrate by in situ hybridization that profilin-III mRNA is localized to cells in the late stage of (C) 2002 Elsevier Science B.V. All rights reserved.