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Journal Article

beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons77799

Brakebusch,  C.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons77945

Fässler,  R.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Brakebusch, C., Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., et al. (2002). beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity, 16(3), 465-477.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6FA2-B
Abstract
Several experimental evidences suggested that beta1 integrin- mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.