English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase

MPS-Authors
/persons/resource/persons78204

Kelm,  O.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons78459

Nigg,  E. A.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Sumara, I., Vorlaufer, E., Stukenberg, P. T., Kelm, O., Redemann, N., Nigg, E. A., et al. (2002). The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase. Molecular Cell, 9(3), 515-525.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-6FA0-F
Abstract
The separation of sister chromatids in anaphase depends on the dissociation of cohesin from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the onset of anaphase by proteolytic cleavage. In contrast, the bulk of cohesin is removed from chromosomes already in prophase and prometaphase by an unknown mechanism that does not involve cohesin cleavage. We show that Polo-like kinase is required for the cleavage- independent dissociation of cohesin from chromosomes in Xenopus. Cohesin phosphorylation depends on Polo-like kinase and reduces the ability of cohesin to bind to chromatin. These results suggest that Polo-like kinase regulates the dissociation of cohesin from chromosomes early in mitosis.