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Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: Tumor cell lines reveal subgroup-specific differences

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons77764

Biesinger,  B.
Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Reiss, C., Niedobitek, G., Hor, S., Lisner, R., Friedrich, U., Bodemer, W., et al. (2002). Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: Tumor cell lines reveal subgroup-specific differences. Virology, 294(1), 31-46.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6F92-D
Abstract
Efficiency of lymphoma induction by herpesvirus saimiri (HVS) isolates correlates with the genetically defined viral subgroups A, B, and C. To compare subgroup-specific effects, highly susceptible tamarins were infected with HVS strain A-11, B-SMHI, or C-488. All animals developed T-cell lymphomas indistinguishable with respect to clinical, pathological, and virological parameters. Ex vivo T-cell lines were established readily from the HVS C-488 animal, less efficiently in the presence of HVS A-11, and from only a single HVS B-SMHI sample. These cultivated cells revealed strain-specific biochemical characteristics. HVS A-11 strongly induced the expression of tyrosine kinase Lyn. HVS C-488 led to the activation of STAT3, which is most likely linked to the association of virus-encoded Tip with tyrosine kinase Lck. The lack of these activities in HVS B-SMHI-transformed cells may correlate with the reduced oncogenic phenotype of this virus in species other than tamarins. (C) 2002 Elsevier Science (USA).