de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

From UBA to UBX: new words in the ubiquitin vocabulary

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons77822

Buchberger,  A.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Buchberger, A. (2002). From UBA to UBX: new words in the ubiquitin vocabulary. Trends in Cell Biology, 12(5), 216-221.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6F48-6
Abstract
Ubiquitination is a versatile tool of eukaryotic cells for controlling the stability, function and subcellular localization of proteins. The variety of cellular processes regulated by ubiquitination demands high substrate specificity of the ubiquitination machinery as well as the existence of diverse downstream effector proteins interacting with ubiquitinated substrates. Most of these cellular effectors are characterized by a modular composition of ubiquitin-binding motifs and further domains mediating specific functions. Here, I give an overview of important ubiquitin-related protein motifs, including the UBA, UIM, UBD and UBX domains, and propose a model for the role of subclasses of UBA-domain- containing proteins in ubiquitin-mediated proteolysis.