de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The centrosome cycle

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons78390

Meraldi,  P.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78459

Nigg,  E. A.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Meraldi, P., & Nigg, E. A. (2002). The centrosome cycle. FEBS Letters, 521(1-3), 9-13.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6EF6-8
Abstract
The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.