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The centrosome cycle

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons78390

Meraldi,  P.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78459

Nigg,  E. A.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Meraldi, P., & Nigg, E. A. (2002). The centrosome cycle. FEBS Letters, 521(1-3), 9-13.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-6EF6-8
Zusammenfassung
The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.