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Chemical genetics: tailoring tools for cell biology

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons78375

Mayer,  T. U.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Mayer, T. U. (2003). Chemical genetics: tailoring tools for cell biology. Trends in Cell Biology, 13(5), 270-277.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-6C0D-6
Abstract
Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.