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The integrin-actin connection, an eternal love affair

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons77799

Brakebusch,  C.
Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons77945

Fässler,  R.
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Brakebusch, C., & Fässler, R. (2003). The integrin-actin connection, an eternal love affair. EMBO Journal, 22(10), 2324-2333.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-6BEB-7
Zusammenfassung
Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.