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Journal Article

Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity

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Domazet-Lošo,  Tomislav
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Hemmrich, G., Khalturin, K., Boehm, A.-M., Puchert, M., Anton-Erxleben, F., Wittlieb, J., et al. (2012). Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Molecular Biology and Evolution, 29(11), 3267-3280. doi:10.1093/molbev/mss134.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-20E9-C
Abstract
How distinct stem cell populations originate and whether there is a clear stem cell “genetic signature” remain poorly understood.
Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position.
In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set
of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication.
Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal
and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common,
multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.