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History Distribution Matching Method for Predicting Effectiveness of HIV Combination Therapies

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons44156

Bogojeska,  Jasmina
Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society;

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Zitation

Bogojeska, J. (2011). History Distribution Matching Method for Predicting Effectiveness of HIV Combination Therapies. In J. Shawe-Taylor, R. S. Zemel, P. Bartlett, F. Pereira, & K. Q. Weinberger (Eds.), Advances in Neural Information Processing Systems 24 (pp. 424-432). La Jolla, CA: NIPS Foundation.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-1341-D
Zusammenfassung
This paper presents an approach that predicts the effectiveness of HIV combination therapies by simultaneously addressing several problems affecting the available HIV clinical data sets: the different treatment backgrounds of the samples, the uneven representation of the levels of therapy experience, the missing treatment history information, the uneven therapy representation and the unbalanced therapy outcome representation. The computational validation on clinical data shows that, compared to the most commonly used approach that does not account for the issues mentioned above, our model has significantly higher predictive power. This is especially true for samples stemming from patients with longer treatment history and samples associated with rare therapies. Furthermore, our approach is at least as powerful for the remaining samples.