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Journal Article

A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites

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Citation

Thomas, M., Moeller, F., Wiehe, T., & Tautz, D. (2007). A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites. Molecular Ecology Notes, 7(3), 400-403. doi:10.1111/j.1471-8286.2007.01697.x.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-0E17-1
Abstract
We have evaluated a pooling approach that can reduce the number of polymerase chain reactions in a screen for selective sweeps by more than an order of magnitude. We show that the complex peak pattern that results from pooling of all samples from a given population is a faithful reflection of the composite pattern of the individual alleles, although with an under-representation of the larger alleles. Candidate loci for selective sweeps can be identified by visual inspection of the pool patterns. We have also implemented a software tool, which can find suitable microsatellite loci in the vicinity of annotated genes.