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Evidence for population growth in humans is confounded by fine- scale population structure

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons72914

Ptak,  Susan E.
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons72913

Przeworski,  Molly
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Zitation

Ptak, S. E., & Przeworski, M. (2002). Evidence for population growth in humans is confounded by fine- scale population structure. Trends in Genetics, 18(11), 559-563.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-0745-6
Zusammenfassung
Although many studies have reported human polymorphism data, there has been no analysis of the effect of sampling design on the patterns of variability recovered. Here, we consider which factors affect a summary of the allele-frequency spectrum. The most important variable to emerge from our analysis L is the number of ethnicities sampled: studies that sequence individuals from more ethnicities recover more rare alleles. These observations are consistent with fine-scale geographic differentiation as well as population growth. They suggest that the geographic sampling strategy should be considered carefully, especially when the aim is to infer the demographic history of humans.