de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Fascin controls neuronal class-specific dendrite arbor morphology

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons45835

Nagel,  Julia
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons71872

Zhang,  Yun
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons39095

Tavosanis,  Gaia
Research Group: Dendrite Differentiation / Tavosanis, MPI of Neurobiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Nagel, J., Delandre, C., Zhang, Y., Foerstner, F., Moore, A. W., & Tavosanis, G. (2012). Fascin controls neuronal class-specific dendrite arbor morphology. DEVELOPMENT, 139(16), 2999-3009. doi:10.1242/dev.077800.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-EECE-E
Abstract
The branched morphology of dendrites represents a functional hallmark of distinct neuronal types. Nonetheless, how diverse neuronal class-specific dendrite branches are generated is not understood. We investigated specific classes of sensory neurons of Drosophila larvae to address the fundamental mechanisms underlying the formation of distinct branch types. We addressed the function of fascin, a conserved actin-bundling protein involved in filopodium formation, in class III and class IV sensory neurons. We found that the terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not. In class III neurons, fascin controls the formation and dynamics of terminal branchlets. Previous studies have shown that transcription factor combinations define dendrite patterns; we find that fascin represents a downstream component of such programs, as it is a major effector of the transcription factor Cut in defining class III-specific dendrite morphology. Furthermore, fascin defines the morphological distinction between class III and class IV neurons. In fact, loss of fascin function leads to a partial conversion of class III neurons to class IV characteristics, while the reverse effect is obtained by fascin overexpression in class IV neurons. We propose that dedicated molecular mechanisms underlie the formation and dynamics of distinct dendrite branch types to elicit the accurate establishment of neuronal circuits.