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Journal Article

Parasites and individual major histocompatibility complex diversity—an optimal choice?

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons56989

Wegner,  K. Mathias
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons56756

Kalbe,  Martin
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons56904

Schaschl,  Helmut
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons56884

Reusch,  Thorsten B. H.
Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Wegner, K. M., Kalbe, M., Schaschl, H., & Reusch, T. B. H. (2004). Parasites and individual major histocompatibility complex diversity—an optimal choice? Microbes and Infection, 6(12), 1110-1116. doi:doi:10.1016/j.micinf.2004.05.025.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-DA7E-5
Abstract
Overdominant selection or heterozygote advantage can partly explain the extraordinary polymorphism found at classical major histocompatibility complex (MHC) loci. However, several studies employing only single infectious agents often failed to detect it. Here, we review recent studies suggesting that due to the dominant nature of MHC-mediated resistance, a heterozygote advantage is most likely to be detected in multiple pathogen challenges.