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Journal Article

Dynamics of haemopoiesis across mammals


Traulsen,  Arne
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Dingli, D., Traulsen, A., & Pacheco, J. M. (2008). Dynamics of haemopoiesis across mammals. Proceedings of the Royal Society B, 275(1649), 2389-2392. doi:10.1098/rspb.2008.0506.

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Haemopoiesis is a fundamental physiologic process found in many animals. Among mammals, the diversity in size and function required suitable adaptations of this process. In this work, we use allometric principles to determine whether this required a change in the basic architecture of haemopoiesis. We show that it is possible to express both the number and rate with which haemopoietic stem cells replicate as well as total marrow output across all mammals as a function of adult mass. This unified view, which is compatible with the existing data, suggests that there was no need for major adaptations in the architecture of haemopoiesis across mammals.